徐书华简介资料介绍
姓名：徐书华中科院特聘教授研究员博士生导师
所在院所：生命科学与技术学院、中国科学院上海营养与健康研究所
课题组简介
研究方向：群体基因组学
研究内容：
1.群体遗传学参数估计和微观进化机制研究；2.现代人群的遗传结构研究；3.混合人群的历史和复杂性状基因定位研究；4.利用混合人群的特征进行基因交互作用研究；5.现代人群对环境的适应及自然选择研究。
代表性论文（*第一作者，#通讯作者）
1.Deng,Lian*;Hoh,Boon-Peng;Lu,Dongsheng;Saw,Woei-Yuh;Ong,Rick Twee-Hee;Kasturiratne,Anuradhani;de Silva,H.Janaka;Zilfalil,Bin Alwi;Kato,Norihiro;Wickremasinghe,Ananda R.;Teo,Yik-Ying;Xu,Shuhua#.Dissecting the genetic structure and admixture of four geographical Malay populations.SCIENTIFIC REPORTS.23 Sep 2015.5.
2.Wang,Yuchen*;Lu,Dongsheng;Chung,Yeun-Jun;Xu,Shuhua#.Genetic structure,divergence and admixture of Han Chinese,Japanese and Korean populations.HEREDITAS.06 Apr 2018.155.
3.Yew,Chee Wei*;Hoque,Mohd Zahirul;Pugh-Kitingan,Jacqueline;Minsong,Alexander;Voo,Christopher Lok Yung;Ransangan,Julian;Lau,Sophia Tiek Ying;Wang,Xu;Saw,Woei Yuh;Ong,Rick Twee-Hee;Teo,Yik-Ying;Xu,Shuhua;Hoh,Boon-Peng;Phipps,Maude E.;Kumar,S.Vijay#.Genetic relatedness of indigenous ethnic groups in northern Borneo to neighboring populations from Southeast Asia,as inferred from genome-wide SNP data.ANNALS OF HUMAN GENETICS.Jul 2018.82(4):216-226.
4.Yew,Chee-Wei*;Lu,Dongsheng;Deng,Lian;Wong,Lai-Ping;Ong,Rick Twee-Hee;Lu,Yan;Wang,Xiaoji;Yunus,Yushimah;Aghakhanian,Farhang;Mokhtar,Siti Shuhada;Hoque,Mohammad Zahirul;Voo,Christopher Lok-Yung;Rahman,Thuhairah Abdul;Bhak,Jong;Phipps,Maude E.;Xu,Shuhua;Teo,Yik-Ying;Kumar,Subbiah Vijay#;Hoh,Boon-Peng#.Genomic structure of the native inhabitants of Peninsular Malaysia and North Borneo suggests complex human population history in Southeast Asia.HUMAN GENETICS.Feb 2018.137(2):161-173.
5.Ni,Xumin*;Yang,Xiong;Guo,Wei;Yuan,Kai;Zhou,Ying;Ma,Zhiming#;Xu,Shuhua#.Length Distribution of Ancestral Tracks under a General Admixture Model and Its Applications in Population History Inference.SCIENTIFIC REPORTS.28 Jan 2016.6.
6.Ni,Xumin*;Yuan,Kai;Yang,Xiong;Feng,Qidi;Guo,Wei;Ma,Zhiming#;Xu,Shuhua#.Inference of multiple-wave admixtures by length distribution of ancestral tracks.HEREDITY.Jul 2018.121(1):52-63.
7.Fu,Ruiqing*;Mokhtar,Siti Shuhada;Phipps,Maude Elvira;Hoh,Boon-Peng;Xu,Shuhua#.A genome-wide characterization of copy number variations in native populations of Peninsular Malaysia.EUROPEAN JOURNAL OF HUMAN GENETICS.Jun 2018.26(6):886-897.
8.Deng,Lian*;Xu,Shuhua#.Adaptation of human skin color in various populations.HEREDITAS.15 Jun 2017.155.
9.Zhang,Cheng*;Lu,Jianqi;Lou,Haiyi;Du,Renqian;Xu,Shuhua;Shen,Yiping;Zhang,Feng#;Jin,Li#.CNVbase:Batch identification of novel and rare copy number variations based on multi-ethnic population data.JOURNAL OF GENETICS AND GENOMICS.20 Jul 2017.44(7):367-370.
10.Liu,Xuanyao*;Lu,Dongsheng;Saw,Woei-Yuh;Shaw,Philip J.;Wangkumhang,Pongsakorn;Ngamphiw,Chumpol;Fucharoen,Suthat;Lert-itthiporn,Worachart;Chin-inmanu,Kwanrutai;Tran Nguyen Bich Chau;Anders,Katie;Kasturiratne,Anuradhani;de Silva,H.Janaka;Katsuya,Tomohiro;Kimura,Ryosuke;Nabika,Toru;Ohkubo,Takayoshi;Tabara,Yasuharu;Takeuchi,Fumihiko;Yamamoto,Ken;Yokota,Mitsuhiro;Mamatyusupu,Dolikun;Yang,Wenjun;Chung,Yeun-Jun;Jin,Li;Hoh,Boon-Peng;Wickremasinghe,Ananda R.;Ong,RickTwee-Hee;Khor,Chiea-Chuen;Dunstan,Sarah J.;Simmons,Cameron;Tongsima,Sissades;Suriyaphol,Prapat;Kato,Norihiro;Xu,Shuhua;Teo,Yik-Ying#.Characterising private and shared signatures of positive selection in 37 Asian populations.EUROPEAN JOURNAL OF HUMAN GENETICS.Apr 2017.25(4):499-508.
11.Qin,Pengfei*;Zhou,Ying;Lou,Haiyi;Lu,Dongsheng;Yang,Xiong;Wang,Yuchen;Jin,Li;Chung,Yeun-Jun;Xu,Shuhua#.Quantitating and Dating Recent Gene Flow between European and East Asian Populations.SCIENTIFIC REPORTS.02 Apr 2015.5.
12.Deng,Lian*;Ruiz-Linares,Andres;Xu,Shuhua#;Wang,Sijia#.Ancestry variation and footprints of natural selection along the genome in Latin American populations.SCIENTIFIC REPORTS.18 Feb 2016.6.
13.Wu,Sijie*;Tan,Jingze;Yang,Yajun;Peng,Qianqian;Zhang,Manfei;Li,Jinxi;Lu,Dongsheng;Liu,Yu;Lou,Haiyi;Feng,Qidi;Lu,Yan;Guan,Yaqun;Zhang,Zhaoxia;Jiao,Yi;Sabeti,Pardis;Krutmann,Jean;Tang,Kun;Jin,Li#;Xu,Shuhua#;Wang,Sijia#.Genome-wide scans reveal variants at EDAR predominantly affecting hair straightness in Han Chinese and Uyghur populations.HUMAN GENETICS.Nov 2016.135(11):1279-1286.
14.Jha,Pankaj*;Lu,Dongsheng;Xu,Shuhua#.Natural Selection and Functional Potentials of Human Noncoding Elements Revealed by Analysis of Next Generation Sequencing Data.PLOS ONE.08 Jun 2015.10(6).
15.Takeuchi,Fumihiko#*;Katsuya,Tomohiro;Kimura,Ryosuke;Nabika,Toru;Isomura,Minoru;Ohkubo,Takayoshi;Tabara,Yasuharu;Yamamoto,Ken;Yokota,Mitsuhiro;Liu,Xuanyao;Saw,Woei-Yuh;Mamatyusupu,Dolikun;Yang,Wenjun;Xu,Shuhua;Teo,Yik-Ying;Kato,Norihiro#.The fine-scale genetic structure and evolution of the Japanese population.PLOS ONE.Nov 2017.12(11).
