张大兵简历资料
上海交通大学教授、生命科学技术学院原副院长
张大兵（1967年7月-2023年6月22日），教授，博士。生前任上海交通大学生命科学技术学院副院长、博士生导师。
张大兵教授是生命科学技术学院发育生物学学科带头人；国家杰出青年基金获得者（2007年）、上海市优秀学科带头人（2007年）和国家百千万人才工程入选者（2009年）、上海科技启明星、上海市曙光学者、教育部新世纪优秀人才等。[2]
2023年6月22日，张大兵遭遇重大交通事故，经抢救无效，不幸逝世，享年56岁。[15]
中文名张大兵国籍中国民族汉族出生日期1967年7月逝世日期2023年6月22日主要成就上海科技启明星、上海市曙光学者、教育部新世纪优秀人才职称教授
人物生平
江苏省淮安市淮阴区西宋集人;
1967年7月生；
1985年－1987年，徐州师范学院（徐州师范大学），生物系；
1987年－1991年，淮安市淮阴区刘老庄中学任教；
1991年－1994年，南京大学，生物系植物学专业；1994年－1998年，中国科学院上海植物生理生态研究所，分子遗传学；
1998年－2005年，上海市农业科学院，生物技术研究中心，植物分子生物学实验室主任、助理研究员、副研究员、研究员；
2005年－至今，上海交通大学，生命科学技术学院，教授、特聘教授，发育生物学学科带头人；国家杰出青年基金获得者、上海市优秀学科带头人和国家百千万人才工程入选者、上海科技启明星、上海市曙光学者、教育部新世纪优秀人才等。
2014年11月9日，在中国生物工程学会2014年学术年会上，张大兵教授以“转基因生物分子特征检测新技术研究”为题作了学术报告。[13]
2016年6月12日当选第五届农业转基因生物安全委员会委员。[1]
2020年，张大兵当选为学院第一届师资队伍建设委员会常务委员。[12]
2023年6月22日，张大兵遭遇重大交通事故，经抢救无效，不幸逝世，享年56岁。[15]
主要研究
1、植物生殖发育生物学：利用正反向遗传学、生物化学、生物信息学、基因组学、蛋白组学、生理学、结构生物学等手段研究模式植物水稻、拟南芥花器官、花粉等发生和形态建成（图1）的分子机理，研究这些器官形成过程中细胞程序性死亡、脂肪和糖代谢、信号传导等控制机制。
2、小分子RNA：研究控制植物发育重要的miRNA表达调控机制(图2)。
3、生物和食品安全检测和相关数据库：利用荧光实时定量PCR、生物传感、基因芯片、重组抗体、分子印迹等技术检测食品中转基因、农兽药残留检测新技术新方法，并进行标准化和应用研究（图3）；同时开展生物安全数据库研究。
所获荣誉
曾获上海市科技启明星（2001年）、上海市曙光学者（2004年）、教育部新世纪优秀人才（2004年）、2007年获国家杰出青年科学基金和上海市优秀学科带头人等称号。2004和2005年分别获得省部级科技进步一等奖，分别为第一和第二完成人。
2018年11月27日，张大兵教授荣膺发展中国家科学院农业科学奖。[14]
据爱思唯尔(Elsevier)发布的榜单，张大兵入选2020“中国高被引学者”。[11]
主要论文
（*为通讯作者）
2011
1)Zhang DB*,Luo X,Zhu L,Cytological analysis and genetic control of rice anther development,J Genet Genomics,38(9)(2011),379-390.
2)Chen WW,Yu XH,Zhang K,Shi JX,Schreiber L,Shanklin J,Zhang DB*,Male Sterile 2 Encodes a Plastid-localized Fatty Acyl ACP Reductase Required for Pollen Exine Development in Arabidopsis thaliana,Plant Physiology,157(2)(2011),842-853.
3)Li HF,Liang WQ,Hu Y,Zhu L,Yin CS,Xu J,Dreni L,Kater MM,Zhang DB*,Rice MADS6 Interacts with the Floral Homeotic Genes SUPERWOMAN1,MADS3,MADS58,MADS13,and DROOPING LEAF in Specifying Floral Organ Identities and Meristem Fate,The Plant Cell.23(7)(2011),2536-2552.
4)Shi J,Tan HX,Yu XH,Liu YY,Liang WQ,Ranathunge K,Franke RB,Schreiber L,Wang YJ,Kai GY,Shanklin J,Ma H,Zhang DB*,Defective Pollen Wall(DPW)Is Required for Anther and Microspore Development in Rice and Encodes a Fatty Acyl ACP Reductase,The Plant Cell.23(6)(2011),2225-2246.
5)Hu LF,Liang WQ,Yin CS,Cui X,Zong J,Wang X,Hu JP and Zhang DB*,Rice MADS3 regulates ROS homeostasis during late anther development,The Plant Cell,23(2)(2011),515-533.
6)Zhang Z,Zhang Y,Tan HX,Wang Y,Li G,Liang WQ,Yuan Z,Hu JP,Ren HY,and Zhang DB*,RICE MORPHOLOGY DETERMINANT encodes the type II formin FH5 and regulates rice morphogenesis,The Plant Cell,23(2)(2011),681-700.
7)Li H,Yuan Z,Vizcay-Barrena G,Yang C,Liang W,Zong J,Wilson ZA,Zhang DB*,PERSISTENT TAPETAL CELL 1(PTC1)Encodes a PHD-Finger Protein That Is Required for Tapetal Cell Death and Pollen Development in Rice,Plant Physiology,156(2)(2011),615-630.
8)Li HF,Liang WQ,Yin CS,Zhu L,Zhang DB*,Genetic Interaction of OsMADS3,DROOPING LEAF,and OsMADS13 in Specifying Rice Floral Organ Identities and Meristem Determinacy,Plant Physiology,156(2011),263-274.
2010
1)Xu J,Yang CY,Yuan Z,Zhang DS,Gondwe MY,Ding ZW,Liang WQ,Zhang DB*,and Wilson ZA,The ABORTED MICROSPORES Regulatory Network Is Required for Postmeiotic Male Reproductive Development in Arabidopsis thaliana,The Plant Cell,22(1)(2010),91-107.
2)Wang CM,Xu J,Zhang DS,Wilson ZA,and Zhang DB*,An effective approach for identification of in vivo protein-DNA binding sites from paired-end ChIP-Seq data,BMC Bioinformatics,11(2010),81.
3)Li H,Pinot F,Sauveplane V,Werck-Reichhart D,Diehl P,Schreiber L,Franke R,Zhang P,Chen L,Gao YW,Liang WQ,and Zhang DB*,Cytochrome P450 Family Member CYP704B2 Catalyzes the omega-Hydroxylation of Fatty Acids and Is Required for Anther Cutin Biosynthesis and Pollen ExineFormation in Rice,The Plant Cell,22(1)(2010),173-190.
4)Li H,and Zhang DB*,Biosynthesis of anther cuticle and pollen exine in rice,Plant Signaling&Behavior,5(9)(2010),1121-1123.
5)Li HF,Liang WQ,Jia RD,Yin CS,Zong J,Kong HZ,and Zhang DB*,The AGL6-like geneOsMADS6 regulates floral organ and meristem identities in rice,Cell Research,20(3)(2010)299-313.
6)Hu LF,Tan HX,Liang WQ,and Zhang DB*,The Post-meiotic Deficicent Anther1(PDA1)gene is required for post-meiotic anther development in rice,Journal Genetics Genomics,37(1)(2010),1-10.
7)Zhang H,Liang WQ,Yang XJ,Luo X,Jiang N,Ma H,and Zhang DB*,Carbon Starved AntherEncodes a MYB Domain Protein That Regulates Sugar Partitioning Required for Rice Pollen Development,The Plant Cell,22(3)(2010),672-689.
8)Zhang X,Zong J,Liu JH,Yin JY and Zhang DB*,Genome-wide analysis of WOX gene family in rice,sorghum,maize,Arabidopsis and poplar,Journal of Integrative Plant Biology,52(11)(2010),1016-1026.
9)Zhang DS,Liang WQ,Yin C,Zong J,Gu F,and Zhang DB*,OsC6,encoding a lipid transfer protein(LTP),is required for postmeiotic anther development in rice,Plant Physiology,154(1)(2010),149-162.
10)Shen HF,Qian BJ,Yang LT,Liang WQ,Chen WW,Liu JH,and Zhang DB*,Estimation of thehomoplasmy degree for transplastomic tobacco using quantitative real-time PCR,European Food Research and Technology,231(1)(2010),143-150.
11)Liu ZH,Bao WJ,Liang WQ,Yin JY,and Zhang DB*,Identification of gamyb-4 and analysis of the regulatory role of GAMYB in rice anther development,Journal of Integrative Plant Biology,52(7)(2010),670-678.
12)Gao XC,Liang WQ,Yin CS,Ji SM,Wang HM,Su X,Guo CC,Kong HZ,Xue HW,Zhang DB*,The SEPALLATA-like gene OsMADS34 is required for rice inflorescence and spikelet,Plant Physiology,153(2)(2010),728-740.
13)Jiang LX,Yang LT,Rao J,Guo JC,Wang S,Liu J,Lee SH,and Zhang DB*,Development and in-house validation of the event-specific qualitative and quantitative PCR detection methods for genetically modified cotton MON15985,Journal Science Food Agriculture,90(3)(2010),402-408.
14)Guan XY,Guo JC,Shen P,Yang LT,and Zhang DB*,Visual and rapid detection of two genetically modified soybean events using Loop-mediated Isothermal Amplification method,Food Analytical Methods,3(4)(2010),313-320.
15)Liu DE,Shen J,Yang LT,Zhang DB*,Evaluation of the impacts of different nuclear DNA content in the hull,endosperm,and embryo of rice seeds on GM rice quantification,Journal of Agriculture Food Chemistry,58(8)(2010),4582-4587.
16)Wang C,Jiang LX,Rao J,Liu YN,Yang LT,Zhang DB*,Evaluation of four genes in rice for their suitability as endogenous reference standards in quantitative PCR,Journal of Agriculture Food Chemistry,58(22)(2010),11543-11547.
17)Xiang Li,Kailin Shen,Litao Yang,Shu Wang,Liangwen Pan,Zhang DB*,Applicability of a novel reference molecule suitable for event-specific detections of maize NK603 based on both 5¡ˉand 3¡ˉflanking sequences,Food Control,21(6)(2010),927-934.
18)Wei JL,XuM,Zhang DB*,and Mi HL*,The role of carotenoid isomerase in maintenance of photosynthetic oxygen evolution in rice plant,Acta Biochimica et Biophysica Sinica,42(7)(2010),457-63.
2009
1)Yuan Z,Gao S,Xue DW,Luo D,Li LT,Ding SY,Yao X,Wilson ZA,Qian Q,and Zhang DB*,RETARDED PALEA1(REP1)controls palea development and floral zygomorphy in rice,Plant Physiology,149(1)(2009),235-244.
2)Zhang DB*,and Wilson ZA,Stamen specification and anther development in rice,Chinese Science Bulletin,54(14)(2009),2342-2353.
5)Wilson ZA*,and Zhang DB,From Arabidopsis to rice,pathways in pollen development,Journal of Experimental Botany,60(5)(2009),1479-1492.
6)Zong J,Yao X,Yin JY,Zhang DB*and Ma H*,Evolution of the RNA dependent RNA polymerase(RdRP)genes,duplications and possible losses before and after the divergence of major eukaryotic groups,Gene,447(1)(2009),29-39.
7)Wang S,Li X,Yang LT,Shen KL,and Zhang DB*,Development and in-house validation of a reference molecule pMIR604 for simplex and duplex event-specific identification and quantification of GM maize MIR604,European Food Research and Technology,230(2)(2009),239-248.
8)Liu J,Guo JC,Zhang HB,Li N,Yang LT,and Zhang DB*,Development and in-house validation of the event-specific polymerase chain reaction detection methods for genetically modified soybean MON89788 based on the cloned integration flanking sequence,Journal of Agriculture Food Chemistry,57(22)(2009),10524-10530.
9)Li X,Yang LT,Zhang JZ,Wang S,Shen KL,Pan LW,and Zhang DB*,Simplex and duplex PCR analysis of Herculex RW(59122)maize based on one reference molecule including separated fragments of 5¡ˉintegration site and endogenous gene,Journal of AOAC International,92(5)(2009),1472-1483.
10)Zhang HB,Yang LT,Guo JC,Li XH,Feng YM,and Zhang DB*,Simultaneous detection of Listeriamonocytogenes,Staphylococcus aureus,Salmonella enterica and Escherichia coli O157,H7 in food samples using multiplex PCR method Journal of Food Safety,29(3)(2009),348-363.
11)Guo JC,Yang LT,Liu X,Zhang HB,Qian BJ,and Zhang DB*,Applicability of the Chymopapain gene used as endogenous reference gene for transgenic Huanong No,1 papaya detection,Journal of Agriculture Food Chemistry,57(15)(2009),6502-6509.
12)Guo JC,Yang LT,Liu X,Guan XY,Jiang LX,and Zhang DB*,Characterization of the exogenous insert and development of event-specific PCR detection methods for genetically modified Huanong No,1 papaya,Journal of Agriculture Food Chemistry,57(16)(2009),7205-7212.
13)Jiang LX,Yang LT,Zhang HB,Guo JC,Marco M,Van den EG,and Zhang DB*,International collaborative study of the endogenous reference gene,Sucrose Phosphate Synthase(SPS),used for qualitative and quantitative analysis of genetically modified rice,Journal of Agriculture Food Chemistry,57(9)(2009),3525-3532.
14)Qu GR,Zheng SL,Liu YM,Xie W,Wu AB,and Zhang DB*,Metal ion mediated synthesis of molecularly imprinted polymers targeting tetracyclines in aqueous samples,Journal of Chromatography B,877(27)(2009),3187-3193.
15)Zheng SL,Song SQ,Huo L,Qu GR,Li RX,Wu AB,and Zhang DB*,A newly combined method of molecularly imprinted solid phase extraction with ELISA for rapid detection of clenbuterol in animal tissue samples,Analytical Letters,42(3)(2009),600-614.
16)Yang LT,Jiang LX,Shen KL,Guo JC,Rao J,Lee SH,and Zhang DB*,Event-specific Qualitative and Quantitative PCR Detection Methods for Genetically Modified Cotton MON88913,Food Safety Quality&Detection Technology,1(2009),10-19.
2008
1)Yang LT,Guo JC,Zhang HB,Liu J,and Zhang DB*,Qualitative and quantitative event-specific PCR detection methods for oxy-235 canola based on the 3'integration flanking sequence,Journal of Agriculture Food Chemistry,56(6)(2008),1804-1809.
2)Yang LT,Zhang HB,Guo JC,Pan LW,and Zhang DB*,International collaborative study for the endogenous reference gene,LAT52,used for qualitative and quantitative analysis of genetically modified tomato,Journal of Agriculture Food Chemistry,56(10)(2008),3438-3443.
3)Dong W,Yang LT,Shen KL,Kim BH,Kleter GA,Marvin HJP,Guo R,Liang WQ,and Zhang DB*,GMDD,a database of GMO detection methods,BMC Bioinformatics,9(2008),260.
4)Yang LT,Liang WQ,Jiang LX,Li WQ,Cao W,Wilson ZA,and Zhang DB*,A novel universal real-time PCR system using the attached universal duplex probes for quantitative analysis of nucleic acids,BMC Molecular Biology,9(2008),54.
5)Zhang DS,Liang WQ,Yuan Z,Lia N,Shi J,Wang J,Liu YM,Yu WJ,and Zhang DB*,Tapetum Degeneration Retardation is critical for aliphatic metabolism and gene regulation during rice pollen development,Molecular Plant,1(4)(2008),599-610.
6)Zhang HB,Yang LT,Guo JC,Jiang LX,and Zhang DB*,Development of one novel multiple-target plasmid for duplex quantitative PCR analysis of roundup ready soybean,Journal of Agriculture Food Chemistry,56(14)(2008),5514-5520.
7)Wu AB,Chen HD,Tang ZZ,and Zhang DB*,Synthesis of Drosophila melanogasteracetylcholinesterase gene using yeast preferred codons and its expression in Pichia pastoris,Chemico-Biological Interactions,175(1-3)(2008),403-405.
8)Song SQ,Wu AB,Shi XZ,Li RX,Lin ZX,and Zhang DB*,Development and application of molecularly imprinted polymers as solid-phase sorbents for erythromycin extraction,Analytical and Bioanalytical Chemistry,390(8)(2008),2141-2150.
9)Qu GR,Wu AB,Shi XZ,Niu ZF,Xie W,and Zhang DB*,Improvement on analyte extraction by molecularly imprinted polymer microspheres toward enrofloxacin,Analytical letters,41(8)(2008),1443-1458.
10)Song SQ,Shi XZ,Li RX,Lin ZX,Wu AB*,and Zhang DB*,Extraction of chlorpromazine with a new molecularly imprinted polymer from pig urine,Process Biochemistry,43(11)(2008),1209-1214.
11)Chen HD,Zuo,XL,Tang ZZ,Wu AB,Song SP,and Zhang DB*,Fan CH,An electrochemical sensor for pesticide assays based on carbon nanotube-enhanced acetycholinesterase activity,The analyst,133(9)(2008),1182-1186.
2007
1)Yang LT,Guo JC,Pan AH,Zhang HB,Zhang KW,Wang ZM,and Zhang DB*,Event-specific quantitative detection of nine genetically modified maizes using one novel standard reference molecule,Journal of Agriculture Food Chemistry,55(1)(2007),15-24.
2)Shi XZ,Wu AB,Li RX,and Zhang DB*,Preparation of molecularly imprinted polymer microspheres for solid-phase extraction of chloramphenicol residue in foods,Journal of Chromatography B,850(1-2)(2007),24-30.
3)Xu SC,Wu AB,Xu YQ,and Zhang DB*,Production of novel recombinant Drosophila melanogasteracetylcholinesterase for detection of organophosphate and carbamate insecticide residues,BiomolecularEngineering,24(2)(2007),253-261.
4)Shi XZ,Wu AB,Qu GR,Li RX,and Zhang DB*,Development and characterisation of molecularly imprinted polymers based on methacrylic acid for selective recognition of drugs,Biomaterials,28(25)(2007),3741-3749.
5)Qian BJ,Shen HF,Liang WQ,Guo XM,Zhang CM,Wang Y,Li GD,Wu AB,Cao KM,and Zhang DB*,Immunogenicity of recombinant hepatitis B virus surface antigen fused with preS1 epitopes expressed in rice seeds,Transgenic Research,17(4)(2007),621-631.
6)Li X,Jiang DH,Yong KL,and Zhang DB*,Varied transcriptional efficiencies of multiple ArabidopsisU6 small nuclear RNA genes,Journal of Integrative Plant Biology,49(2)(2007),222-229.
7)Chu HW,and Zhang DB*,The shoot apical meristem size regulated by FON4 in rice,Plant Signaling&Behavior,2(2)(2007),e1-e2.
2006
1)Yang LT,Pan AH,Zhang HB,Guo JC,Yin CS,and Zhang DB*,Event-specific qualitative and quantitative polymerase chain reaction analysis for genetically modified canola T45,Journal of Agriculture Food Chemistry,54(26)(2006),9735-9740.
2)Liang WQ,Huang YH,Yang XH,Zhou ZA,Pan AH,Qian BJ,Huang C,Chen JX,and Zhang DB*,Oral immunization of mice with plant derived fimbrial adhesin FaeG induces systemic and mucosal K88ad enterotoxigenic Escherichia coli specific immune responses,FEMS Immunology&Medical Microbiology,46(3)(2006),393-399.
3)Pan AH,Yang LT,Xu SC,Yin CS,Zhang KW,Wang ZY,and Zhang DB*,Event-specific qualitative and quantitative PCR detection of MON863 maize based upon the 3¡ˉ-transgene integration sequence,Journal of Cereal Science,43(2)(2006),250-257.
4)Li N,Zhang DS,Liu HS,Yin CS,Li XX,Liang WQ,Yuan Z,Xu B,Chu HW,Wang J,Wen TQ,Huang H,Luo D,Ma H,and Zhang DB*,The rice Tapetum Degeneration Retardation gene is required for tapetum degradation and anther development,The Plant Cell,18(11)(2006),2999-3014.
5)Chu HW,Qian Q,Liang WQ,Yin CS,Tan HX,Yao X,Yuan Z,Yang J,Huang H,Luo D,Ma H,andZhang DB*,The FLORAL ORGAN NUMBER4 gene encoding a putative ortholog of Arabidopsis CLAVATA3 regulates apical meristem size in rice,Plant Physiology,142(3)(2006),1039-1052.
6)Li XX,Duan XP,Jiang HX,Sun YJ,Tang YP,Yuan Z,Guo JK,Liang WQ,Chen L,Wang J,Ma H,Yin JY,and Zhang DB*,Genome-Wide Analysis of Basic/Helix-Loop-Helix Transcription Factor Family in Rice and Arabidopsis,Plant Physiology,141(4)(2006),1167-1184.
7)Jiang DH,Yin CS,Yu AP,Zhou XF,Liang WQ,Yuan Z,Xu Y,Yu QB,Wen TQ,and Zhang DB*,Duplication and expression analysis of multicopy miRNA gene family members in Arabidopsis and rice,Cell Research,16(5)(2006),507-518.
8)Qian BJ,Shen HF,Xiong JJ,Chen L,Zhang L,Jia JW,Wang Y,Zhang ZC,Yuan Z,Cao KM,andZhang DB*,Expression and purification of the synthetic preS1 gene of Hepatitis B Virus with preferred Escherichia coli codon preference,Protein Expression and Purification,48(1)(2006),74-80.[[fulltext
2005
1)Yang LT,Pan AH,Zhang KW,Yin CS,Qian BJ,Chen JX,Huang C,and Zhang DB*,Qualitative and Quantitative PCR Methods for Event-specific Detection of Genetically Modified Cotton Mon1445 and Mon531,Transgenic Research,14(6)(2005),817-831.
2)Huang YH,Liang WQ,Wang YJ,Zhou ZA,Pan AH,Yang XH,Huang C,Chen JX,and Zhang DB*,Immunogenicity of the epitope of the foot and mouth disease virus fused with a hepatitis B core protein as expressed in transgenic tobacco,Viral Immunology,18(4)(2005),668-677.
3)Yang LT,Pan AH,Zhang KW,Guo JC,Yin CS,Chen JX,Huang C,and Zhang DB*,Identification and quantification of three genetically modified insect resistant cotton lines using conventional and TaqMan real-time polymerase chain reaction methods,Journal of Agriculture Food Chemistry,53(16)(2005),6222-6229.
4)Yang LT,Chen JX,Huang C,Jia SR,Liu YH,Pan LW,and Zhang DB*,Validation of a cotton specific gene,Sad1,used as an endogenous reference gene in qualitative and real-time quantitative PCR detection of transgenic cottons,Plant Cell Reporter,24(4)(2005),237-245.
5)Yang LT,Shen HF,Pan AH,Chen JX,Cheng H,and Zhang DB*,Screening and construct specific detection methods of transgenic Huafan No,1 tomato by conventional and real-time PCR,Journal of Science Food Agriculture,85(13)(2005),2159-2166.
6)Yang LT,Xu SC,Pan AH,Yin CS,Zhang KW,Wang ZY,Zhou ZG,and Zhang DB*,Event-specific qualitative and quantitative PCR detection of genetically modified MON863 maize based on the 5¡ˉ-transgene integration sequence,Journal of Agriculture Food Chemistry,53(24)(2005),9312-9318.
7)Weng HB,Yang LT,Liu ZL,Ding JY,Pan AH,and Zhang DB*,A novel reference gene,High-mobility-group protein I/Y,can be used in qualitative and real-time quantitative PCR detection of transgenic rapeseeds,Journal of AOAC International,88(2)(2005),577-584.
8)Yang LT,Ding JY,Zhang CM,Jia JW,Weng HB,Liu WX,and Dabing Zhang*,Estimating the copy number of transgenes in transformed rice by real-time quantitative PCR,Plant Cell Reporter,23(10-11)(2005),759-763.
9)Yang LT,Pan AH,Jia JW,Ding JY,Chen JX,Huang C,Zhang CM,and Zhang DB*,Validation of a tomato specific gene,LAT52,used as an endogenous reference gene in qualitative and real-time quantitative PCR detection of transgenic tomatoes,Journal of Agriculture Food Chemistry,53(2)(2005),183-190.
10)Liu HS,Chu HW,Hui Li,Wang HM,Wei JL,Li N,Ding SY,Huang H,Ma H,Huang CF,Luo D,Yuan Z,Liu JH,and Zhang DB*,Genetic analysis and mapping of rice(Oryza sativa L,)male-sterile(OsMS-L)mutant,Chinese Science Bulletin,50(2)(2005),122-125.
11)Li H,Xu L,Wang H,Yuan Z,Cao XF,Yang ZN,Zhang DB,Xu Y,and Huang H*,The Putative RNA-dependent RNA polymerase RDR6 acts synergistically with ASYMMETRIC LEAVES1 and 2 to repressBREVIPEDICELLUS and MicroRNA165/166 in Arabidopsis leaf development,The Plant Cell,17(8)(2005),2157-2171.
2004
1)Zhao MW,Liang WQ,Wang N,Zhang DB*,Pan YJ,and Jong SC,Analysis of sqialene synthase expression during the development of Ganaderma lucidum,Journal of Microbiology Biotechnology,14(1)(2004),116-120.
2)Ding JY,Jia JW,Yang LT,Wen HB,Zhang CM,Liu WX,and Zhang DB*,Validation of a rice specific gene,Sucrose Phosphate Synthase,used as the endogenous reference gene for qualitative and real-time quantitative PCR detection of transgenes,Journal of Agriculture Food Chemistry,52(11)(2004),3372-3377.
3)Cheng H,Lu JH,Liang WQ,Huang YH,Zhang WJ,and Zhang DB*,Purification of the recombiant heptatis B virus core antigen(rHBcAg)produced in the yeast Saccaromyces cerevisiae and comparative observation of its particles by transmission eletron microscopy(TEM)and atomic microscopy(AFM),Mircon,35(5)(2004),311-318.
4)Weng HB,Pan AH,Yang LT,Zhang CM,Liu ZL,and Zhang DB*,Estimating transgene copy number by real-time PCR assay using HMG I/Y as an endogenous reference gene in transgenic rapeseed,Plant Molecular Biology Reporter,22(3)(2004),289-300.
5)Zhang HB,Zhang DB,Chen J,Yang YH,Huang ZJ,Huang DF,Wang XC,and Huang RF,Tomato stress-responsive factor TSRF1 interacts with ethylene responsive element GCC box and regulates pathogen resistance to Ralstonia solanacearum,Plant Molecular Biology,55(6)(2004),825-834.
2003
1)Gao HW,Zhang DB,Pan AH,Liang WQ,and Liang CZ,A multiplex-PCR method for detection bovine materials in foodstuffs,Journal of AOAC International,86(4)(2003),764-767.
2)Huang YH,Liang WQ,Pan AH,Zhou ZA,Cheng H,Chen JX,and Zhang DB*,Production of FaeG,the major subunit of K88 fimbriae,in transgenic tobacco plants and its immunogenicity in mice,Infection and Immunity,71(9)(2003),5436-5439.
3)Zhang YL,Zhang DB*,Li WQ,Chen JQ,Peng YF,and Cao W,A novel real-time quantitative PCR method using attached universal template probe,Nucleic Acids Research,31(20)(2003),e123 p1-8.
2001
1)Meng YL,Wang YM,Zhang DB,and NII NS,Isolation of a choline monooxygenase cDNA clone from Amaranthus tricolor and its expressions under stress conditions,Cell Research,11(3)(2001),187-193.
研究成果
在水稻生殖发育方面开展了大量研究工作，近年来分离鉴定了10余个控制水稻花粉形成、花序和花器官发育相关的关键基因，并阐明了其作用机制。另外，在转基因生物安全性检测方面在国内外率先寻找并验证了适合转基因油菜、棉花、番茄和水稻中外源基因定性、定量PCR检测的内标准基因，建立了我国主要转基因农产品检测方法，对于保障转基因生物安全消费具有重要促进作用。2003年至今以通讯作者身份在Plant Cell等期刊上发表80多篇高质量研究论文，申请专利14项（其中两项为国际PCT专利），获得授权专利6项。申请水稻新品种保护2项；负责和参与制定国家技术标准20余项，制定ISO标准4项。
人物言论
2013年7月12日，张大兵教授做客人民网“再论转基因”系列访谈，张大兵认为，“转基因产品的标识制度”不会成为转基因产品和技术的灭顶之灾，但“标识制度带来的副作用必须要予以考虑”。一方面，强制标识措施的实施，就相当于给“转基因”贴上了嫌疑犯的标签，反过来又强化了民众对“转基因”的抵触情绪。“这可能会影响民众对非转基因产品的购买欲望”；另一方面，标识制度的实施，会大大提高转基因产品的市场成本，加大消费者的负担，降低其市场竞争力。[3]
张大兵表示，“我个人认为对可以标识转基因产品加贴标签，让消费者自由选择是否购买转基因产品，满足消费者的选择权和知情权，是好事情”。[4]
2017年9月，张大兵撰文指出：转基因生物安全问题是一个复杂的综合性问题，它对人类社会的影响远远超过了人们的预期，那种希望仅靠科学技术的完善来解决人们对转基因生物安全的疑虑和不安的想法显然过于纯真。[5]
张大兵指出：各国监管机构的监管实践证明，经过严格的科学评估、批准上市的转基因产品是安全的，没有发生一例被科学证明的转基因安全事件。[6]
张大兵说：转基因生物安全或不安全都要遵循科学评估原则，以科学评估结果为准，是否安全应是权威机构说了算，应更多地听取同行专家群体意见。[7]
张大兵说：和历史上其他新技术（如wifi）或新产品（比如阿司匹林）面市所受到的反应不一样，转基因生物或产品一方面在全球得到了大面积推广和应用，取得了令人瞩目的成就，另一方面也承受着全球范围的抵制和诋毁，这种尴尬局面的形成很明显已经超出了科学本身，彰显背后各种政治、经济、文化、宗教、伦理和其他势力的角力。[8]
张大兵进一步说：因此，转基因生物安全不是单纯的科学问题，转基因生物安全争论的实质也不是安全问题。因此，转基因生物技术的缺陷、产品的瑕疵或管理的漏洞往往被无限放大，并演变成为争论焦点，混淆了对转基因生物安全的科学认知和技术认同，引发无数的争论。[9]
2019年3月9日，张大兵表示，“英才计划”培养的重点，不单是教授学生知识，更重要的是激发学生的学习兴趣，培养学生的自主学习能力，提高学生的创造力，这样培养出来的学员才是未来最具有潜力的优秀人才。[10]
参考资料
1国家农业转基因生物安全委员名单公示：院士14名．网易科技[引用日期2016-06-17]
2张大兵．上海交通大学植物发育生物学实验室．2014-12-12[引用日期2021-03-29]
3我院张大兵教授做客人民网“再论转基因”系列访谈【图】．上海交通大学生命科学技术学院．2013-07-15[引用日期2021-03-31]
4我院张大兵教授做客人民网“再论转基因”系列访谈【图】．上海交通大学生命科学技术学院．2013-07-15[引用日期2021-04-03]
5张大兵:转基因生物安全争论的实质不是安全问题．中国乡村发现．2017-09-13[引用日期2021-04-06]
6张大兵:转基因生物安全争论的实质不是安全问题．中国乡村发现．2017-09-13[引用日期2021-04-08]
7张大兵:转基因生物安全争论的实质不是安全问题．中国乡村发现．2017-09-13[引用日期2021-04-10]
8张大兵:转基因生物安全争论的实质不是安全问题．中国乡村发现．2017-09-13[引用日期2021-04-12]
9张大兵:转基因生物安全争论的实质不是安全问题．中国乡村发现．2017-09-13[引用日期2021-04-14]
10张大兵：授人以鱼不如授人以渔．新华网．2019-03-09[引用日期2021-04-28]
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